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Gastrointestinal Imaging

E2953. Radiologic Spectrum of Osseous Metastasis in Hepatocellular Carcinoma

Peckham M,  Nicola R,  Goldstein A,  Karam A,  Foley K. University of Massachusetts Memorial Medical Center, Worcester, MA

Address correspondence to M. Peckham (

Background Information: The skeletal system is one of the most common sites of extrahepatic metastasis of hepatocellular carcinoma (HCC), including recurrence following liver transplantation. Current surveillance guidelines focus on imaging of the liver using ultrasound or cross-sectional imaging or both. Failure to identify osseous metastases in patients with HCC can potentially result in both inaccurate staging and inappropriate therapy.

Educational Goals/Teaching Points: Participants will be exposed to the various osseous manifestations of HCC. The correlative radiologic findings with the corresponding biopsy results are discussed.

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques: An exhibit involving a wide spectrum of biopsy-proven cases of osseous metastasis in patients with HCC in both the axial and appendicular skeleton are discussed. These examples are demonstrated across all modalities (plain radiography, MDCT, and MRI).

Conclusion: After this exhibit, participants will become more cognizant of the osseous manifestation of hepatocellular carcinoma.