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E2811. Hippocampal Volumetry in Normal Adult Indian Population on 1.5-T MRI

Inampudi V,  Inampudi R,  Myneni D. PES Institute of Medical Sciences and Research Foundation, Kuppam, India

Address correspondence to V. Inampudi (

Objective: The purpose of this study was to calculate the volume of hippocampus in a normal adult Indian population and to know the differences between sex and side.

Materials and Methods: We conducted a prospective study in which we selected 950 consecutive cases, referred to the Department of Radiodiagnosis between January 2015 and July 2017. The images were done using Siemens Magnetom Avanto 1.5-T MRI machine. all patients between 18 and 40 years of age who were referred to the Department of Radiodiagnosis for MRI of brain were included. Patients with mesial temporal sclerosis or other lesions involving the temporal lobe and patients presenting with seizures were excluded. Scanning parameters were—conventional T1- and T2-weighted sequences in axial, sagittal, and coronal planes; coronal oblique FLAIR sequence (3 mm thick with a 1.5-mm gap); 3D volume acquisition inversion recovery T1 images in oblique plane (slice thickness, 1 mm; interslice gap, 1 mm); and manual segmentation and volumetry done using Siemens Syngo software.

Results: We studied a total of 950 cases, which included 64% men and 36% women. A mean hippocampal volume of 2.48 cm3 was found in the study. The right hippocampus was larger than the left, with a mean volume of 2.51 cm3 and 2.45 cm3, respectively. A mean right hippocampal volume of 2.56 cm3 in men and 2.46 cm3 in women was obtained. The mean left hippocampal volume was 2.48 cm3 in men and 2.41 cm3 in women. Hippocampal volume was significantly higher in men.

Conclusion: TThe hippocampal volume was significantly higher in men and was significantly higher on the right compared to the left side. We did not detect any significant differences associated with age. However, other studies showed that hippocampal volume regresses with progression of age due to age-related atrophy of the brain. The mean hippocampal volume in the Indian population was smaller compared to literature based on the Western population; however, it was similar to other Asian studies. We attempted to define the normative data for hippocampal volume in the Indian population. MRI brain with hippocampal volumetry was significantly helpful to evaluate patients with intractable seizures like mesial temporal sclerosis. The values obtained here may be adopted as a standard in the evaluation of Indian patients with intractable epilepsy.